pleroma.debian.social

pleroma.debian.social

Jonathan Dowland | @jmtd@pleroma.debian.social

Principal Software Engineer on #OpenJDK #RedHat. #Debian developer (dormant). Computer Science PhD student. Amateur Computing historian (Computer Science and H/W, esp. Commodore Amiga). Guerilla archivist.

@algernon congratulations. I need to catch up on your work and put mitigations in on my VPS at some point. A little niche media wiki instance is now shifting 3GiB/day

The plural of regex is regrets 😂

@ifixcoinops there’s probably a secret group of folks hoarding the last working sandisk Sansa fuzes. Absolutely wonderful little machines.

@cstross @IngaLovinde @ifixcoinops I’ve got one of those. Easy hack to use sd cards, supported by rock box. Bright, colourful aftermarket facias If that’s your thing. Really nice to use

I can hardly believe it’s been a decade since Pratchett died. I might start a partial re-read of discworld.

@Mycroft @NanoRaptor isn’t that a skinny puppy song?

I might have a White Goth T Shirt problem
A collection of white goth tee shirts

@GyrosGeier @cstross @MishaVanMollusq I don't know if Hamilton has any connection to the localities connected by the (real) A1(M), but when "The Great North Road" came out he did a double-act signing tour with Stephen Baxter, who (probably coincidentally) does.

@GyrosGeier @cstross @MishaVanMollusq I’m utterly convinced that book references the A1(M) deliberately.

The PineNote is here! I'm planning on making a hands on video to share my experience. Let me know if you have any questions you want me to try and answer. I don't plan to do technical tests but open to collaborating on it.

First impression, feels like a quality and sturdy device. Feels good in the hand, the texture is a kinda soft grippy plastic. Pen felt good, the writing friction seems ok, I don't want to make any software qualifications until I update the device but still happy with the out-of-box experience. The wake from sleep time is essentially instant.

@PINE64 great work on the PineNote, I'm very impressed with the hardware!

Edit 2: there's renewed interest in this post, feel free to check out the first impressions video (~6 mins, which has a good bit of usage footage), in case that post isn't visible to you.

Edit: Link to blog post with thoughts after day one. Since I'm on a single user instance most people may not see the thread with info that hasn't been boosted, the post has all of it.

#Pine64 #PineNote #OpenHardware #OpenHardware #FOSS

A PineNote e-ink tablet with a pen on it is placed on a black mat with white grids along a collection of various coins down the side for a size comparison. The coins are (top to bottom):
Canadian 2 dollars
Mexican 10 pesos
Japanese 500 ten
UK 1 pound
US 25 cents

@purpleidea does that component still use bugzilla? I thought everything moved to JIRA

Umm, this is big COVID vaccine news. Nobody tell RFK Jr.

Original thread at link below.

THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution.

The study has been published in Science. YES, it is PEER-REVIEWED. https://www.science.org/doi/10.1126/scitranslmed.adq5720

🧵 https://bsky.app/profile/sailorrooscout.bsky.social/post/3ljxftvw5x22h

Abstract
The ongoing emergence of severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants of concern that reduce the effectiveness of antibody therapeutics necessitates development of next-generation antibody modalities that are resilient to viral evolution. Here, we characterized amino-terminal domain (NTD) - and receptor binding domain (RBD)-specific monoclonal antibodies previously
isolated from COVID-19 convalescent donors for their activity against emergent
SARS-CoV-2 VOCs.
Among these, NTD-specific antibody C1596
displayed the greatest breadth of binding to VOCs, with cryo-electron microscopy structural analysis revealing recognition of a distinct NTD epitope outside of the site i antigenic supersite. Given C1596's
favorable binding profile, we designed a series of bispecific antibodies (bsAbs), termed CoV2-biRNs, that featured both NTD & RBD specificities.
Two of the C1596-inclusive bsAbs, CoV2-biRN5 and CoV2-biRN7, retained potent in vitro neutralization activity against all Omicron variants tested, including XBB.1.5, BA.2.86, and JN.1, contrasting the diminished potency of parental antibodies delivered as monotherapies or as a cocktail. Furthermore, prophylactic delivery of CoV2-biRN5 reduced viral load within the lungs of K18-hACE2 mice after challenge with SARS-CoV-2 XBB.1.5. In conclusion, NTD-RBD bsAbs offer promising potential for the design of resilient, next-generation antibody therapeutics against SARS-CoV-2 VOCs. Diagram showing NTD Antibody + RBD Antibody leading to a combination labeled CoV2-biRN More realistic diagram rather than the previous geometric one, showing NTD and RBD before and after the new approach has attached itself.

When I submit this thesis I’m going to need to remember how to relax again

@mirabilos For the Moon project, IDK. I might prefer not to rule myself out ;) Also, did it actually land in the end? I can't recall

Given it’s international women’s day, I’d like to encourage you all, but especially Dutch men to read these ‘anti-acknowledgments’ in a PhD thesis. This is not from somewhere else, it’s from Delft. And it’s not from the 1950s, but from the present. Unfortunately what academic life and culture in The Netherlands is still like. The author is just one of the few who actually spoke up about it, but there are many stories like it.

(Alt at https://pastebin.com/cqLvxX1f)

Text did not fit so I posted it here https://pastebin.com/cqLvxX1f

Pleased to discover the Journal of Functional Programming has an rss (or atom) feed https://www.cambridge.org/core/journals/journal-of-functional-programming

Must remember to add “my code is on the Moon and Mars” to my CV

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